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Monoamine oxidase (MAO) inhibitors (except low doses of selective MAO-B inhibitors) and Sinemet should not be given concomitantly. These inhibitors must be discontinued at least 2 weeks prior to initiating therapy with Sinemet.
Sinemet is contraindicated in patients with known hypersensitivity to this drug and in patients with narrow-angle glaucoma.
Since levodopa may activate a malignant melanoma, Sinemet should not be used in patients with suspicious undiagnosed skin lesions or a history of melanoma.
